TTC21B 抗体 (AA 1221-1316) (Cy3)
Quick Overview for TTC21B 抗体 (AA 1221-1316) (Cy3) (ABIN1412865)
抗原
See all TTC21B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1221-1316
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交叉反应
- 大鼠
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预测反应
- Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human TTC21B
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- TTC21B (Tetratricopeptide Repeat Domain 21B (TTC21B))
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别名
- TTC21B
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背景
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Synonyms: ATD4, JBTS11, Nbla10696, NPHP12, Putative protein product of Nbla10696, Tetratricopeptide repeat protein 21B, THM1, TPR repeat protein 21B, TT21B_HUMAN, Ttc21b.
Background: The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
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基因ID
- 79809
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UniProt
- Q7Z4L5
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途径
- Hedgehog Signaling
抗原
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