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DOK4 抗体 (AA 22-98) (Cy5)

This Cy5-conjugated 兔 多克隆 anti-DOK4 antibody specifically detects DOK4 in WB, IF (cc) 和 IF (p). The antibody is reactive with 人 samples.
产品编号 ABIN1411444
发货至: 中国
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Quick Overview for DOK4 抗体 (AA 22-98) (Cy5) (ABIN1411444)

抗原

See all DOK4 抗体
DOK4 (Docking Protein 4 (DOK4))

适用

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宿主

  • 50

克隆类型

  • 50
多克隆

标记

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This DOK4 antibody is conjugated to Cy5

应用范围

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Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 14
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 22-98

    预测反应

    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human DOK4

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    DOK4 (Docking Protein 4 (DOK4))

    别名

    DOK4

    背景

    Synonyms: docking protein 4, Downstream of tyrosine kinase 4, FLJ10488, DOK4_HUMAN.

    Background: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

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