UNC5B 抗体 (AA 188-260) (Cy5)
Quick Overview for UNC5B 抗体 (AA 188-260) (Cy5) (ABIN1409476)
抗原
See all UNC5B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 188-260
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human UNC5B
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亚型
- IgG
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anti-Netrin receptor UNC5B (UNC5B) (AA 404-517) antibody
UNC5B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 188-260) antibodyUNC5B 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 27-126) antibodyUNC5B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A9 unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 507-541) antibodyUNC5B 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB52980 unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 27-126) antibodyUNC5B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 629-643) antibodyVerified UNC5B 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 290-377) antibodyUNC5B 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- UNC5B (Netrin receptor UNC5B (UNC5B))
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别名
- UNC5B/UNC5H2
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背景
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Synonyms: Netrin receptor UNC5B, Netrin receptor UNC5B Precursor, p53 regulated receptor for death and le, p53 regulated receptor for death and le protein 1, p53-regulated receptor for death and le protein 1, p53RDL1, Protein unc-5 homolog 2, Protein unc-5 homolog B, Protein XUNC 5, Transmembrane receptor Unc5H2, Unc 5 homolog 2, Unc 5 homolog B, UNC 5B, Unc5 C.elegans homolog b, Unc5b, UNC5B_HUMAN, UNC5H2.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.
抗原
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