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ATRIP 抗体 (pSer68, pSer72) (HRP)

ATRIP 适用: 人 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal HRP
产品编号 ABIN1407902
发货至: 中国
  • 抗原 See all ATRIP 抗体
    ATRIP (ATR Interacting Protein (ATRIP))
    抗原表位
    • 25
    • 14
    • 11
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer68, pSer72
    适用
    • 71
    • 20
    • 19
    • 1
    • 1
    宿主
    • 66
    • 5
    克隆类型
    • 65
    • 6
    多克隆
    标记
    • 39
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATRIP antibody is conjugated to HRP
    应用范围
    • 47
    • 28
    • 14
    • 14
    • 14
    • 13
    • 8
    • 8
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic phosphopeptide derived from human ATRIP around the phosphorylation site of Ser68 + Ser72 [LA(p-S)QAL(p-S)QC]
    亚型
    IgG
    Top Product
    Discover our top product ATRIP Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    注意事项
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    ATRIP (ATR Interacting Protein (ATRIP))
    别名
    ATRIP+ (ATRIP 产品)
    别名
    6620401K05Rik antibody, TREX1 antibody, Xatrip antibody, trex1 antibody, si:dkey-42i9.5 antibody, ATRIP antibody, CG7347 antibody, Dmel\\CG7347 antibody, Mus304 antibody, anon-WO0140519.82 antibody, atrip antibody, mus(3)304 antibody, mus-304 antibody, ATR interacting protein antibody, ATR interacting protein S homeolog antibody, mutagen-sensitive 304 antibody, ATRIP, ATR checkpoint kinase regulatory subunit Rad26 antibody, ATRIP antibody, Atrip antibody, atrip.S antibody, atrip antibody, mus304 antibody, rad26 antibody
    背景

    Synonyms: ATRIP phospho S68 + S72, ATRIP Ser68 + Ser72, P-ATRIP Ser68/Ser72, AGS 1, AGS1, AGS-1, Aicardi Goutieres syndrome 1, ATIP, ATM and Rad3 related interacting protein, ATM and Rad3-related-interacting protein, ATR interacting protein, ATR-interacting protein, Atrip, ATRIP_HUMAN, Deoxyribonuclease III dnaQ/mutD E. coli like, DKFZp434J0310, DKFZp762J2115, DNase III, DRN 3, DRN3, FLJ12343, MGC20625, MGC26740, Three prime repair exonuclease 1, TREX 1, TREX1, TREX1 protein, MGC21482, 3' repair exonuclease 1, 3'-5' exonuclease TREX1.

    Background: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.

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