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FBXO21 抗体 (AbBy Fluor® 350)

This AbBy Fluor® 350-conjugated 兔 多克隆 anti-FBXO21 antibody specifically detects FBXO21 in WB 和 IF (p). The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN1400949
发货至: 中国
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北京 101111
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for FBXO21 抗体 (AbBy Fluor® 350) (ABIN1400949)

抗原

See all FBXO21 抗体
FBXO21 (F-Box Protein 21 (FBXO21))

适用

  • 41
  • 33
  • 24
  • 6
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  • 2
  • 2
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  • 2
  • 1
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人, 小鼠, 大鼠

宿主

  • 33
  • 10

克隆类型

  • 35
  • 8
多克隆

标记

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  • 2
  • 2
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  • 1
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  • 1
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  • 1
  • 1
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This FBXO21 antibody is conjugated to AbBy Fluor® 350

应用范围

  • 43
  • 18
  • 12
  • 10
  • 9
  • 8
  • 6
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human FBXO21

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    FBXO21 (F-Box Protein 21 (FBXO21))

    别名

    FBXO21

    背景

    Synonyms: F box only protein 21, F box protein 21, F-box only protein 21, FBX21, FBX21_HUMAN, Fbxo21, FLJ90233, KIAA0875, MGC26682.

    Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

    基因ID

    23014
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