Glutathione Synthetase 抗体 (AA 81-160) (Biotin)
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Quick Overview for Glutathione Synthetase 抗体 (AA 81-160) (Biotin) (ABIN1393693)
抗原
See all Glutathione Synthetase (GSS) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 81-160
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Sheep,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Glutathione Syntase
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亚型
- IgG
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anti-Glutathione Synthetase (GSS) antibody
GSS 适用: 人, 大鼠, 犬 WB, IF, FACS 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Glutathione Synthetase (GSS) (AA 373-474) antibodyKO Validated GSS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) antibodyKD Validated GSS 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4385 unconjugated Recombinant Antibody
anti-Glutathione Synthetase (GSS) (AA 290-418) antibodyGSS 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) antibodyGSS 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B6 unconjugated
anti-Glutathione Synthetase (GSS) (AA 372-400), (C-Term) antibodyGSS 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB39457 unconjugated
anti-Glutathione Synthetase (GSS) (AA 268-474) antibodyGSS 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) antibodyGSS 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Glutathione Synthetase (GSS) (AA 1-474) antibodyGSS 适用: 人 WB, ICC, ELISA, IF 宿主: 小鼠 Monoclonal AT12F2 unconjugated
anti-Glutathione Synthetase (GSS) antibodyGSS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G4-2E9 unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Glutathione Synthetase (GSS)
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别名
- GSS/Glutathione Synthetase
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背景
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Synonyms: Glutathione synthase; GSH S; GSH synthetase; GSH-S; GSHB_HUMAN; GSHS; GSS antibodyMGC14098; OTTHUMP00000030711.
Background: GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with ©-GCS and ending with GSS. In an ATP-dependent reaction, GSS produces Glutathione from ©-glutamylcysteine and glycine precursors. Partial hepatectomy, diethyl maleate, buthionine sulfoximine, tert-butylhaydroquinone and thioacetamide increase the ex-pression of GSS, which causes an increase in Glutathione levels. An inherited autosomal recessive disorder, 5-oxoprolinuria (pyroglutamic aciduria), is caused by GSS deficiencies, which leads to central nervous system damage, hemolytic anemia, metabolic acidosis and urinary excretion of 5-oxoproline. A missense mutation in the gene encoding GSS leads to a GSS deficiency restricted to erythrocytes, which causes only hemolytic anemia.-GCS and ending with GSS.
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途径
- Warburg Effect
抗原
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