CALHM1 抗体 (AA 161-260) (FITC)
Quick Overview for CALHM1 抗体 (AA 161-260) (FITC) (ABIN1392482)
抗原
See all CALHM1 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 161-260
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                                            预测反应
- Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit
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                                            纯化方法
- Purified by Protein A.
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                                            免疫原
- KLH conjugated synthetic peptide derived from human CALHM1/FAM26C
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                                            亚型
- IgG
 
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                                            应用备注
- 
                        IF(IHC-P) 1:50-200
 IF(IHC-F) 1:50-200
 IF(ICC) 1:50-200
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 μg/μL
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                                            缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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                                            有效期
- 12 months
 
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    - CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
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                                            别名
- CALHM1/FAM26C
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                                            背景
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                        Synonyms: CAHM1_HUMAN, Calcium homeostasis modulator 1, Calcium homeostasis modulator protein 1, CALHM1, FAM26C, Family with sequence similarity 26, member C, MGC39514, MGC39617, Protein FAM26C. Background: CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease. 
 抗原
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