HSD17B4 抗体 (AA 521-620) (AbBy Fluor® 555)
Quick Overview for HSD17B4 抗体 (AA 521-620) (AbBy Fluor® 555) (ABIN1390427)
抗原
See all HSD17B4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 521-620
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交叉反应
- 小鼠, 绵羊, 斑马鱼
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预测反应
- Human,Rat,Cow,Pig,Horse,Chicken,Guinea Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2
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亚型
- IgG
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) antibody
HSD17B4 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (N-Term) antibodyHSD17B4 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (C-Term) antibodyHSD17B4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (AA 437-736) antibodyHSD17B4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) antibodyHSD17B4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (AA 510-736) antibodyHSD17B4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (AA 744-761), (C-Term) antibodyHSD17B4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (N-Term) antibodyHSD17B4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) (AA 341-370) antibodyHSD17B4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB31274 unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))
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别名
- HSD17B4
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背景
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Synonyms: hydroxysteroid 17-beta dehydrogenase 4, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, 17 beta HSD 4, 17 beta HSD IV, 17 beta hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, 17-beta-hydroxysteroid dehydrogenase 4, 17beta estradiol dehydrogenase type IV, 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody 3-alpha, 7-alpha, Beta hydroxyacyl dehydrogenase, Beta keto reductase, D 3 hydroxyacyl CoA dehydratase, D bunctional protein, D bunctional protein peroxisomal, D-bunctional protein, DBP, DHB4_HUMAN, EDH17B4, Enoyl-CoA hydratase 2, Hsd17b4, MFE 2, MFE-2, MPF-2, Multunctional protein 2, Peroxisomal multunctional enzyme type 2, Peroxisomal multunctional protein 2, SDR8C1, Short chain dehydrogenase/reductase family 8C member 1.
Background: 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
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途径
- Monocarboxylic Acid Catabolic Process
抗原
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