PRDM1 抗体 (AA 501-600)
Quick Overview for PRDM1 抗体 (AA 501-600) (ABIN1387860)
抗原
See all PRDM1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 501-600
-
交叉反应
- 小鼠
-
预测反应
- Human,Rat,Cow,Pig,Horse,Chicken,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human PRDM1/Blimp1
-
亚型
- IgG
-
-
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 1-109) antibody
PRDM1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (Internal Region) antibodyVerified PRDM1 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 690-825) antibodyPRDM1 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2F1B6 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 1-109) antibodyPRDM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 422-493) antibodyPRDM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G9 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 690-825) antibodyPRDM1 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7C11H1 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (C-Term) antibodyVerified PRDM1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (Middle Region) antibodyPRDM1 适用: 人, 小鼠, 大鼠, 犬, Pig, Cow, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibodyPRDM1 适用: 人, 小鼠, Pig WB, ELISA, IHC, IP, FACS, ICC, IF 宿主: 小鼠 Monoclonal 3H2-E8 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 1-122) antibodyPRDM1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
- PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
-
别名
- PRDM1
-
背景
-
Synonyms: Blimp 1, Blimp-1, B Lymphocyte Induced Maturation Protein 1, Beta interferon gene positive regulatory domain I binding factor, Beta-interferon gene positive regulatory domain I-binding factor, BLIMP-1, BLIMP1, Positive Regulatory Domain I Binding Factor 1, Positive regulatory domain I-binding factor 1, PR Domain Containing 1, PR domain containing 1 with ZNF domain, PR domain containing 1 with ZNF domain isoform 2, PR domain containing protein 1, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI BF1, PRDI binding factor 1, PRDI-BF1, PRDI-binding factor 1, PRDM 1, Prdm1, PRDM1_HUMAN.
Background: The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.
-
基因ID
- 144423
-
途径
- Regulation of Muscle Cell Differentiation
抗原
-
