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SETDB1 抗体 (AA 201-300)

Name: SETDB1 抗体 (AA 201-300)
SKU: ABIN1387645
Availability: OutOfStock

This anti-SETDB1 antibody is a 兔多克隆 antibody detecting SETDB1 in WB, ELISA, IF (cc), IF (p), IP, IHC (p), ICC 和 IHC (fro). Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.

(1 reference)

产品编号 ABIN1387645

发货至: 中国

Quick Overview for SETDB1 抗体 (AA 201-300) (ABIN1387645)

抗原

See all SETDB1 抗体

SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This SETDB1 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product SETDB1 Primary Antibody

抗原表位
14

8

3

3

2

2

1

1

1

1
AA 201-300

交叉反应

大鼠

预测反应

Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human SETDB1

亚型

IgG
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibody
SETDB1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A3 unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibody
SETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) antibody
SETDB1 适用: 人, 小鼠, 猴 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 5H6A12 unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) antibody
SETDB1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5H6D4 unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) antibody
SETDB1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibody
SETDB1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225) antibody
SETDB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibody
SETDB1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225), (C-Term) antibody
SETDB1 适用: 人 WB 宿主: 兔 Polyclonal RB5748 unconjugated

anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1050-1075) antibody
SETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Marco, Kisliouk, Tabachnik, Weller, Meiri et al.: "DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ..." in: Diabetes, Vol. 65, Issue 8, pp. 2258-67, (2016) (PubMed).
抗原

SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

别名

KMT1E/SETDB1

背景

Synonyms: ESET, KG1T, KMT1E, TDRD21, H3-K9-HMTase4, Histone-lysine N-methyltransferase SETDB1, ERG-associated protein with SET domain, Histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, Lysine N-methyltransferase 1E, SET domain bifurcated 1, SETDB1, KIAA0067
Background: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).

基因ID

9869

UniProt

Q15047