DEPTOR 抗体 (AA 56-170)
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北京 101111
Quick Overview for DEPTOR 抗体 (AA 56-170) (ABIN1387597)
抗原
See all DEPTOR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 56-170
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6
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亚型
- IgG
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anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-409) antibody
DEPTOR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 86-120) antibodyDEPTOR 适用: 人 WB 宿主: 兔 Polyclonal RB57442 unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 3-38) antibodyDEPTOR 适用: 人 WB 宿主: 兔 Polyclonal RB57441 unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-409) antibodyDEPTOR 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 1-409) antibodyDEPTOR 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5B3 unconjugated
anti-DEP Domain Containing mTOR-Interacting Protein (DEPTOR) (AA 230-280) antibodyDEPTOR 适用: 人, 大鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress." in: Nucleic acids research, Vol. 46, Issue 18, pp. 9601-9616, (2019) (PubMed).
: "High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma." in: OncoTargets and therapy, Vol. 8, pp. 3449-55, (2015) (PubMed).
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: "Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress." in: Nucleic acids research, Vol. 46, Issue 18, pp. 9601-9616, (2019) (PubMed).
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- DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))
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别名
- Deptor
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背景
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Synonyms: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6, DEPTOR
Background: DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.
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基因ID
- 64798
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UniProt
- Q8TB45
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途径
- PI3K-Akt Signaling, RTK signaling, Regulation of Cell Size, BCR Signaling, Warburg Effect
抗原
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