Dihydrofolate Reductase 抗体
Quick Overview for Dihydrofolate Reductase 抗体 (ABIN1387277)
抗原
See all Dihydrofolate Reductase (DHFR) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- purified by Protein A and peptide affinity chromatography
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免疫原
- KLH conjugated synthetic peptide derived from human DHFR
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亚型
- IgG
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应用备注
- WB (1:100-500),IHC-P (1:100-500),FACS (1:50-200),IF (p) (1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 µg/µL
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缓冲液
- Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C for 12 months
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有效期
- 12 months
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- Dihydrofolate Reductase (DHFR)
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别名
- DHFR
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背景
- DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of DNA synthesis and cell death. Gene expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
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分子量
- 21kDa
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基因ID
- 1719
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HGNC
- 0
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途径
- Mitotic G1-G1/S Phases
抗原
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