Glutathione Synthetase 抗体 (AA 81-160)
Quick Overview for Glutathione Synthetase 抗体 (AA 81-160) (ABIN1386180)
抗原
See all Glutathione Synthetase (GSS) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 81-160
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Dog,Cow,Sheep,Pig,Horse
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human Glutathione Syntase
-
亚型
- IgG
-
-
anti-Glutathione Synthetase (GSS) antibody
GSS 适用: 人, 大鼠, 犬 WB, IF, FACS 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Glutathione Synthetase (GSS) (AA 373-474) antibodyKO Validated GSS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) (AA 290-418) antibodyGSS 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) antibodyGSS 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4B6 unconjugated
anti-Glutathione Synthetase (GSS) (AA 372-400), (C-Term) antibodyGSS 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB39457 unconjugated
anti-Glutathione Synthetase (GSS) (AA 268-474) antibodyGSS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) antibodyGSS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G4-2E9 unconjugated
anti-Glutathione Synthetase (GSS) antibodyGSS 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) (AA 270-474) antibodyGSS 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Synthetase (GSS) (AA 270-474) antibodyGSS 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
- Glutathione Synthetase (GSS)
-
别名
- GSS/Glutathione Synthetase
-
背景
-
Synonyms: Glutathione synthase; GSH S; GSH synthetase; GSH-S; GSHB_HUMAN; GSHS; GSS antibodyMGC14098; OTTHUMP00000030711.
Background: GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with ©-GCS and ending with GSS. In an ATP-dependent reaction, GSS produces Glutathione from ©-glutamylcysteine and glycine precursors. Partial hepatectomy, diethyl maleate, buthionine sulfoximine, tert-butylhaydroquinone and thioacetamide increase the ex-pression of GSS, which causes an increase in Glutathione levels. An inherited autosomal recessive disorder, 5-oxoprolinuria (pyroglutamic aciduria), is caused by GSS deficiencies, which leads to central nervous system damage, hemolytic anemia, metabolic acidosis and urinary excretion of 5-oxoproline. A missense mutation in the gene encoding GSS leads to a GSS deficiency restricted to erythrocytes, which causes only hemolytic anemia.-GCS and ending with GSS.
-
途径
- Warburg Effect
抗原
-
