SPPL2B 抗体 (AA 55-135)
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- 抗原 See all SPPL2B 抗体
- SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))
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抗原表位
- AA 55-135
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SPPL2B antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SPPL2B
- 亚型
- IgG
- Top Product
- Discover our top product SPPL2B Primary Antibody
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anti-Signal Peptide Peptidase-Like 2B (SPPL2B) (N-Term) antibody
SPPL2B 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Peptide Peptidase-Like 2B (SPPL2B) (N-Term) antibodySPPL2B 适用: 人, 大鼠, Cow, 马, 小鼠, Pig, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Peptide Peptidase-Like 2B (SPPL2B) (AA 492-592) antibodySPPL2B 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Peptide Peptidase-Like 2B (SPPL2B) (AA 126-160) antibodySPPL2B 适用: 人 WB 宿主: 兔 Polyclonal RB53138 unconjugated
anti-Signal Peptide Peptidase-Like 2B (SPPL2B) (AA 196-229) antibodySPPL2B 适用: 人 WB 宿主: 兔 Polyclonal RB53139 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))
- 别名
- IMP4/SPPL2B (SPPL2B 产品)
- 背景
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Synonyms: IMP4, Signal peptide peptidase-like 2B, Intramembrane protease 4, Protein SPP-like 2B, SPPL2B, SPP2B_HUMAN.
Background: SPPL2b is a 592 amino acid multi-pass membrane protein that contains one protease associated domain and belongs to the GXGD family of aspartic proteases. Localized to the membrane of the Golgi apparatus and to lysosomes, endosomes and the plasma membrane, SPPL2b functions as an intramembrane protease that specifically cleaves the transmembrane domain of TNF? Once cleaved, TNF?releases its intracellular domain, thus triggering the immunity-related expression of cytokines (also known as interleukins) which are used in various pathways throughout the body. SPPL2b also interacts with and catalyzes the intramembrane proteolysis of ITM2B (integral membrane protein 2B), a protein that, when mutated, is associated with dementia. Four isoforms of SPPL2b exist due to alternative splicing events.
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