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FBXO21 抗体

FBXO21 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386062
发货至: 中国
  • 抗原 See all FBXO21 抗体
    FBXO21 (F-Box Protein 21 (FBXO21))
    适用
    • 37
    • 35
    • 23
    • 6
    • 5
    • 4
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    • 2
    • 2
    • 1
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    人, 小鼠, 大鼠
    宿主
    • 37
    • 5
    克隆类型
    • 39
    • 3
    多克隆
    标记
    • 18
    • 3
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    • 2
    • 1
    • 1
    • 1
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    This FBXO21 antibody is un-conjugated
    应用范围
    • 42
    • 20
    • 13
    • 12
    • 9
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human FBXO21
    亚型
    IgG
    Top Product
    Discover our top product FBXO21 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    FBXO21 (F-Box Protein 21 (FBXO21))
    别名
    FBXO21 (FBXO21 产品)
    别名
    FBX21 antibody, 2810425J22Rik antibody, AU016673 antibody, mKIAA0875 antibody, si:ch211-42a13.2 antibody, F-box protein 21 antibody, FBXO21 antibody, Fbxo21 antibody, fbxo21 antibody
    背景

    Synonyms: F box only protein 21, F box protein 21, F-box only protein 21, FBX21, FBX21_HUMAN, Fbxo21, FLJ90233, KIAA0875, MGC26682.

    Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

    基因ID
    23014
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