NSMCE2 抗体
-
- 抗原 See all NSMCE2 抗体
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This NSMCE2 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human MMS21/NSE2
- 亚型
- IgG
- Top Product
- Discover our top product NSMCE2 Primary Antibody
-
anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (AA 1-247) antibody
NSMCE2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (AA 1-247) antibodyNSMCE2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (N-Term) antibodyNSMCE2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
- 抗原
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- 别名
- MMS21 (NSMCE2 产品)
- 背景
-
Synonyms: C8orf36, E3 SUMO-protein ligase NSE2, hMMS21, hNSE2, methyl methanesulfonate sensitivity gene 21, MMS21, MMS21 homolog, non-SMC element 2, Non-SMC element 2 homolog, Non-structural maintenance of chromosomes element 2 homolog, NSE2_HUMAN, NSMCE2.
Background: Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex with six conserved nonSMC subunits, including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2. Specifically, this complex is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements. The NSE1 protein contains a RING-like motif that promotes DNA repair functions of the SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells. NSE2 stimulates sumoylation of SMC6 and the DNA repair protein TRAX. Depletion of the NSE2 protein by RNA interference leaves the cell vulnerable to DNA damage-induced apoptosis.
- 基因ID
- 286053
-
