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NCF1 抗体 (pSer359)

NCF1 适用: 大鼠 WB, ELISA, IF (cc), ICC, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1385194
发货至: 中国
  • 抗原 See all NCF1 抗体
    NCF1 (Neutrophil Cytosol Factor 1 (NCF1))
    抗原表位
    • 27
    • 16
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer359
    适用
    • 116
    • 42
    • 36
    • 16
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    大鼠
    宿主
    • 127
    • 2
    • 1
    克隆类型
    • 128
    • 1
    多克隆
    标记
    • 66
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This NCF1 antibody is un-conjugated
    应用范围
    • 97
    • 63
    • 56
    • 25
    • 23
    • 15
    • 14
    • 12
    • 6
    • 6
    • 4
    • 4
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    大鼠
    预测反应
    Human
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
    亚型
    IgG
    Top Product
    Discover our top product NCF1 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Chen, Ye, Zhang, Tang, Li, Lu, Wu, Yu, Kou: "Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils." in: International journal of molecular sciences, Vol. 17, Issue 12, (2016) (PubMed).

  • 抗原
    NCF1 (Neutrophil Cytosol Factor 1 (NCF1))
    别名
    NCF1/p47 phox (NCF1 产品)
    别名
    NCF1A antibody, NOXO2 antibody, SH3PXD1A antibody, p47phox antibody, Ncf-1 antibody, p47 antibody, neutrophil cytosolic factor 1 antibody, NCF1 antibody, Ncf1 antibody
    背景

    Synonyms: NCF1Ser359, p47 phoxSer359, NCF1 phospho S359, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NADPH oxidase organizer 2, NCF 47K, Neutrophil cytosol factor 1, Neutrophil cytosolic factor 1, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox organizing protein 2, NOXO2, p47 phox, p47phox, ,SH3 and PX domain containing protein 1A, SH3PXD1A, NADPH oxidase p47 phox, NCF1_HUMAN.

    Background: The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.

    基因ID
    653361
    途径
    PI3K-Akt Signaling
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