LGR4 抗体
Quick Overview for LGR4 抗体 (ABIN1381741)
抗原
See all LGR4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Anti-human LGR4
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交叉反应
- 小鼠
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产品特性
- Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells
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纯化方法
- Protein G
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免疫原
- genetic immunisation with cDNA encoding human LGR4
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亚型
- IgG2a kappa
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应用备注
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Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. -
说明
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Synonyms: GPR48
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限制
- 仅限研究用
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C
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储存方法
- short term: 2 °C - 8 °C, long term: -20 °C
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- LGR4 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4))
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别名
- LGR4
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背景
- LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4, GPR48) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains. LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart. LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.
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UniProt
- Q9BXB1
抗原
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