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CD28 抗体 (PE)

CD28 适用: 小鸡 FACS 宿主: 小鼠 Monoclonal AV7 PE
产品编号 ABIN135535
发货至: 中国
  • 抗原 See all CD28 抗体
    CD28
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    小鸡
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    小鼠
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    标记
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    This CD28 antibody is conjugated to PE
    应用范围
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    Flow Cytometry (FACS)
    特异性
    Chicken/Turkey CD28, Mr 40-44 kDa
    产品特性
    Mouse Anti-Chicken CD28-PE
    免疫原
    Chicken peripheral blood lymphocytes
    克隆位点
    AV7
    亚型
    IgG1
    Top Product
    Discover our top product CD28 Primary Antibody
  • 应用备注
    • Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Costim - Reported in literature
    • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    说明

    In vitro T-cell costimulation

    样本量
    1 mL
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    0.1 mg in 1.0 mL of PBS/Sodium azide and a stabilizing agent
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze!
    Protect conjugated products from light.

    Each reagent is stable for the period shown on the bottle label if stored as directed.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C
  • 抗原
    CD28
    别名
    CD28 (CD28 产品)
    别名
    Tp44 antibody, CD28RNA antibody, cd28 antibody, CD28 molecule antibody, CD28 antigen antibody, Cd28 molecule antibody, CD28 molecule L homeolog antibody, CD28 antibody, Cd28 antibody, cd28.L antibody
    背景
    Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on Ag presenting cells. Peripheral + T cells are CD28-negative.1 Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MAbs against the avian T cell receptor (TCR). Both V1- and V2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3.
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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