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CD28 抗体

CD28 适用: 小鸡 FACS 宿主: 小鼠 Monoclonal AV7 unconjugated
产品编号 ABIN135532
发货至: 中国
  • 抗原 See all CD28 抗体
    CD28
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    小鸡
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    小鼠
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    标记
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    This CD28 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS)
    特异性
    Chicken/Turkey CD28, Mr 40-44 kDa
    产品特性
    Mouse Anti-Chicken CD28-UNLB
    纯化方法
    Purified
    免疫原
    Chicken peripheral blood lymphocytes
    克隆位点
    AV7
    亚型
    IgG1
    Top Product
    Discover our top product CD28 Primary Antibody
  • 应用备注
    • Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Costim - Reported in literature
    • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    说明

    In vitro T-cell costimulation

    样本量
    1 mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added
    储存液
    Without preservative
    注意事项
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C
  • Cha, Khatri, Mutnal, Sharma: "Pathogenic and immunogenic responses in turkeys following in ovo exposure to avian metapneumovirus subtype C." in: Veterinary immunology and immunopathology, (2010) (PubMed).

  • 抗原
    CD28
    别名
    CD28 (CD28 产品)
    别名
    Tp44 antibody, CD28RNA antibody, cd28 antibody, CD28 molecule antibody, CD28 antigen antibody, Cd28 molecule antibody, CD28 molecule L homeolog antibody, CD28 antibody, Cd28 antibody, cd28.L antibody
    背景
    Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on Ag presenting cells. Peripheral + T cells are CD28-negative.1 Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MAbs against the avian T cell receptor (TCR). Both V1- and V2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3.
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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