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H-2Kd/H-2Dd 抗体 (Biotin)

适用: 小鼠 FACS 宿主: 小鼠 Monoclonal 34-1-2S Biotin
产品编号 ABIN135418
发货至: 中国
  • 抗原
    H-2Kd/H-2Dd
    适用
    小鼠
    宿主
    • 7
    小鼠
    克隆类型
    • 7
    单克隆
    标记
    • 3
    • 2
    • 1
    • 1
    Biotin
    应用范围
    • 7
    • 3
    • 2
    • 1
    Flow Cytometry (FACS)
    特异性
    Mouse H-2Kd/H-2Dd
    产品特性
    Mouse Anti-Mouse H-2Kd/H-2Dd-BIOT
    免疫原
    BDF1 mouse splenocytes
    克隆位点
    34-1-2S
    亚型
    IgG2a
  • 应用备注
    • Applications: FC - Quality tested , ICC - Reported in literature , EM - Reported in literature , IP - Reported in literature , CMCD - Reported in literature , Block - Reported in literature , Adhesion - Reported in literature
    • Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC and BIOT conjugates 1 g/106 cells PE conjugate 0.1 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    说明

    Blocking Cell Adhesion, Complement-mediated cytotoxicity

    样本量
    1 mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    0.5 mg in 1.0 mL of PBS/Sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect conjugated products from light.
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C
  • Abel, Goto, Magnuson, Abraham, Ramanathan, Hotaling, Alaniz, Kumar-Sinha, Dziubinski, Urs, Wang, Shi, Waghray, Ljungman, Crawford, Simeone: "HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties." in: eLife, Vol. 7, (2019) (PubMed).

    Pal, Dziubinski, Di Magliano, Simeone, Owens, Thomas, Peterson, Potu, Talpaz, Donato: "Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 2, pp. 152-164, (2018) (PubMed).

    Chen, Fisher, Signs, Molina, Shenoy, Lopez, Baker, Koomen, Chen, Gittleman, Barnholtz-Sloan, Berg, Appelman, Huang: "Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis." in: Oncotarget, Vol. 8, Issue 31, pp. 50476-50488, (2017) (PubMed).

  • 抗原
    H-2Kd/H-2Dd
    背景
    The classical MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic chains noncovalently associated with the invariant 2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.
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