CD80 抗体
Quick Overview for CD80 抗体 (ABIN135272)
抗原
See all CD80 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- Mouse CD80, Mr 52-55 kDa
-
产品特性
- Rat Anti-Mouse CD80-LE/AF
-
纯化方法
- Ion exchange
-
内毒素水平
- Low endotoxin
-
免疫原
- Activated 5C2 cells
-
亚型
- IgG2a
-
-
-
-
应用备注
-
- Applications: FC - Quality tested , IP - Reported in literature , Block - Reported in literature
- Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
-
说明
-
In vivo and in vitro blocking of ligand binding
-
样本量
- 1 mL
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- 0.5 mg of purified immunoglobulin in 1.0 mL of PBS
-
储存液
- Azide free
-
注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
-
储存条件
- -20 °C
-
储存方法
- Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.
-
-
- CD80
-
别名
- CD80
-
背景
- CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex.
-
途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
-