CD74 抗体 (PE)
Quick Overview for CD74 抗体 (PE) (ABIN192405)
抗原
See all CD74 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD74 PE
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特异性
- The antibody LN2 recognizes an extracellular epitope of CD74 (the MHC II-associated invariant chain, Ii), a type II transmembrane protein expressed in antigen-presenting cells, as well as e.g. on activated neoplastic cells in T cell lymphomas, in lymph node germinal center, mantle zone B cells, histiocytes, interdigitating reticulum cells, Langerhans cells, thymic dendritic cells and peripheral blood B lymphocytes.
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交叉反应 （详细）
- Other not tested
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纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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免疫原
- SU-DHL-4 lymphoma cells
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亚型
- IgG1
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anti-HLA-DR-gamma (CD74) (AA 1-106) antibody
CD74 适用: 人 FACS, WB, ELISA, ICC 宿主: 小鼠 Monoclonal 2D1B3 unconjugated
anti-HLA-DR-gamma (CD74) (AA 78-222) antibodyCD74 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) (AA 64-205) antibodyCD74 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) (AA 1-106) antibodyCD74 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 2D1B11 unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人, 小鼠, Baboon FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal LN-2 unconjugated
anti-HLA-DR-gamma (CD74) (AA 73-232) antibodyCD74 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-HLA-DR-gamma (CD74) antibodyCD74 适用: 人 FACS, WB, IF, IHC, IP, ICC 宿主: 小鼠 Monoclonal PIN-1 unconjugated
anti-HLA-DR-gamma (CD74) (N-Term) antibodyCD74 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
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限制
- 仅限研究用
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
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Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user. -
储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- CD74 (HLA-DR-gamma (CD74))
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别名
- CD74
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背景
- CD74 Molecule,CD74 (the MHC II-associated invariant chain, Ii) is a type II transmembrane protein expressed in antigen-presenting cells, that serves as MHC II chaperone which promotes MHC II trafficking from the ER to endocytic compartments, prevents peptide binding in the ER and contributes to peptide editing in the MHC II compartment, it is also an accessory signaling molecule implicated e.g. in malignant B cell proliferation. Stimulation of cell surface CD74 leads to NFkappaB activation, which enables entry of the stimulated cell into the S phase. CD74 binds pro-inflammatory cytokine MIF with high affinity and interacts with CD44. Binding of Vpu, an HIV1 protein, to CD74 modulates MHC II presentation.,p33, DHLAG, HLADG, Ia-gamma
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基因ID
- 972
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UniProt
- P04233
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途径
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
抗原
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