CRTC1 抗体 (AA 19-34)
Quick Overview for CRTC1 抗体 (AA 19-34) (ABIN129689)
抗原
See all CRTC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-34
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Supplier Product No.
- 600-401-936
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Supplier
- Rockland
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原理
- MECT1 Antibody
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交叉反应 （详细）
- This affinity-purified antibody is directed against human MECT1 protein.
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产品特性
- Synonyms: rabbit anti-MECT1 antibody, MECT-1, MECT 1, TORC1, TORC-1, TORC 1, WAMTP1, WAMTP-1, CRTC1, CRTC-1, CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1, Transducer of regulated cAMP response element-binding protein 1, Transducer of CREB protein 1
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 19-34 of human MECT1 protein.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (pSer151) antibody
CRTC1 适用: 人, 小鸡 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人 WB, IP, FACS, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1B5 unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 1-248) antibodyCRTC1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 553-634) antibodyCRTC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 8F9 unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人, 小鼠 WB, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) antibodyCRTC1 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CREB Regulated Transcription Coactivator 1 (CRTC1) (AA 1-200) antibodyCRTC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Application Note: This affinity-purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 80-95 kDa in size corresponding to MECT1 protein by western blotting in the appropriate cell lysate or extract. This antibody is will react with isoform 1 and 2 of MECT1.
Western Blot Dilution: 1:500 - 1:2,000
ELISA Dilution: 1:10,000 - 1:40,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.95 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
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别名
- CRTC1
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背景
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. MECT1 (also known as Mucoepidermoid Carcinoma Translocated 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. MECT1 enhances the interaction of CREB1 with TAF4. It regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Mect1 is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. MECT1 is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, it is involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. MECT1 may be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, MECT1 regulates the light-induced entrainment of the circadian clock. In response to light stimulus, it coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. Therefore, it has been found to be important for energy balance and reproduction. Anti-MECT1 (CRTC1) Antibody is useful for researchers interested in glucose energy metabolism, circadian rhythms, and hormone research.
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基因ID
- 23373, 148596965
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UniProt
- Q6UUV9
抗原
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