Mre11 抗体 (AA 68-706)
Quick Overview for Mre11 抗体 (AA 68-706) (ABIN129662)
抗原
See all Mre11 (MRE11A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 68-706
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Supplier Product No.
- 600-401-896
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Supplier
- Rockland
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原理
- Mre11 Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against mouse Mre11 protein.
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产品特性
- Synonyms: rabbit anti-Mre11 antibody, Double-strand break repair protein MRE11a, DNA recombination and repair protein, Meiotic recombination 11 homolog A, Mre11a
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 68-706 of mouse Mre11 protein.
Immunogen Type: Recombinant Protein
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亚型
- IgG
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anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 1-205) antibody
MRE11A 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibodyMRE11A 适用: 人, 大鼠, 小鼠, 小鸡, Hamster WB, IHC, IP, IF, ICC, FACS, ChIP 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 451-550) antibodyMRE11A 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 1-205) antibodyMRE11A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 375-609) antibodyMRE11A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 1-205) antibodyMRE11A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (C-Term) antibodyMRE11A 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (Internal Region) antibodyMRE11A 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 2-239) antibodyMRE11A 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) (AA 1-206) antibodyMRE11A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H4-F4 unconjugated
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应用备注
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Application Note: This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 80 kDa in size corresponding to Mre11 by western blotting in the appropriate cell lysate or extract.
Western Blot Dilution: 1:500 - 1:2,000
ELISA Dilution: 1:10,000 - 1:50,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.05 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
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别名
- Mre11a
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背景
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI). Mre11 is a component of the MRN complex (Mre11/Rad50/Nbs1), which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them close. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres, the MRN complex may modulate t-loop formulation. Anti-Mre11 Antibody is useful for researcher interested in DNA Damage and Repair and Nuclear Signaling Research.
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基因ID
- 4361, 18202590
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UniProt
- Q61216
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途径
- DNA Damage Repair
抗原
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