CBLC 抗体 (C-Term)
Quick Overview for CBLC 抗体 (C-Term) (ABIN129659)
抗原
See all CBLC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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Supplier Product No.
- 600-401-889
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Supplier
- Rockland
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原理
- Cbl-c Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against human Cbl-c protein.
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产品特性
- Synonyms: rabbit anti-Cbl-c Antibody, E3 ubiquitin-protein ligase CBL-C, RING finger protein 57, RING-type E3 ubiquitin transferase CBL-C, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C, CBLC, CBL3, RNF57
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-Terminal portion of Human Cbl-c.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Cbl proto-oncogene C (CBLC) (AA 245-474) antibody
CBLC 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 245-474) antibodyCBLC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 3B4 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-474) antibodyCBLC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 244-474) antibodyCBLC 适用: 人 WB 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 424-453), (C-Term) antibodyCBLC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0696 unconjugated
anti-Cbl proto-oncogene C (CBLC) (AA 1-30), (N-Term) antibodyCBLC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0694 unconjugated
anti-Cbl proto-oncogene C (CBLC) antibodyCBLC 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Cbl proto-oncogene C (CBLC) (N-Term) antibodyCBLC 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry Dilution: 1:500 - 1:3,000
Application Note: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, immunoprecipitation and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~52 kDa in size corresponding to Cbl-c by western blotting in the appropriate cell lysate or extract.
Western Blot Dilution: 1:500 - 1:3,000
Immunoprecipitation Dilution: User Optimized
ELISA Dilution: 1:10,000 - 1:50,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.42 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- CBLC (Cbl proto-oncogene C (CBLC))
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别名
- CBLC
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背景
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.
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基因ID
- 23624, 125987803
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UniProt
- Q9ULV8
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途径
- EGFR Signaling Pathway
抗原
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