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DLL4 抗体 (Internal Region)

Name: DLL4 抗体 (Internal Region)
Brand: Rockland
SKU: ABIN1043880
Availability: OutOfStock

This 兔多克隆 antibody specifically detects DLL4 in WB, ELISA 和 IHC. It exhibits reactivity toward 人和小鼠. It has been mentioned in 6+ publications

Western Blot of Rabbit anti-DELTA-4 antibody. (DLL4 抗体 (Internal Region))

Affinity Purified anti-Delta-4 antibody was used at 20 µg/ml to detect Delta-4 in a variety of tissues including colon, liver, skeletal muscle, ovary, pancreas, prostate, testes, thymus, tonsil and uterus. (DLL4 抗体 (Internal Region))

IHC

ELISA

3 images

(6 references)

产品编号 ABIN1043880

Supplier Product No.: 600-401-696s

发货至: 中国

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中国
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Quick Overview for DLL4 抗体 (Internal Region) (ABIN1043880)

抗原

See all DLL4 抗体

DLL4 (delta-Like 4 (DLL4))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This DLL4 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Discover our top product DLL4 Primary Antibody

抗原表位
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Internal Region

Supplier Product No.

600-401-696s

Supplier

Rockland

原理

DELTA-4 Antibody

交叉反应（详细）

DELTA-4 affinity purified antibody is directed against human DELTA-4.

产品特性

Synonyms: rabbit anti-DELTA4 antibody, DELTA-4, delta 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4, notch ligand DLL4 precursor, DELTA 4

纯化方法

The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.

过滤

Sterile filtered

免疫原

Immunogen: Anti-DELTA-4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Human DELTA-4.
Immunogen Type: Conjugated Peptide

亚型

IgG
anti-delta-Like 4 (DLL4) (AA 313-439) antibody
DLL4 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4A11F8 unconjugated

anti-delta-Like 4 (DLL4) antibody
DLL4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A11G2 unconjugated

anti-delta-Like 4 (DLL4) (AA 215-331) antibody
DLL4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-delta-Like 4 (DLL4) antibody
DLL4 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4A11F8 unconjugated

anti-delta-Like 4 (DLL4) antibody
DLL4 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

anti-delta-Like 4 (DLL4) (Internal Region) antibody
DLL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-delta-Like 4 (DLL4) antibody
DLL4 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal 4A11F8-4A11G2 unconjugated

anti-delta-Like 4 (DLL4) (AA 44-345) antibody
DLL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-delta-Like 4 (DLL4) (AA 123-221) antibody
DLL4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-delta-Like 4 (DLL4) antibody (PE)
DLL4 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal HMD4-2 PE

应用备注

Immunohistochemistry Dilution: 10 μg/mL to 20 μg/mL
Application Note: Anti-DELTA-4 has been tested for use in ELISA, immunohistochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 74 kDa in size corresponding to DELTA-4 by western blotting in the appropriate cell lysate or extract. For best results use Goat Serum as blocking agent in western blotting.
Western Blot Dilution: 1:500 - 1:2,500
ELISA Dilution: 1:10,000 - 1:50,000
Other: User Optimized

限制

仅限研究用
状态

Liquid

浓度

0.88 mg/mL

缓冲液

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

有效期

12 months
Wu, Esumi, Watanabe, Chen, Nakamura, Nakamura, Kometani, Minato, Yanagawa, Akashi, Sakimura, Kaneko, Tamamaki: "Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon." in: Development (Cambridge, England), Vol. 138, Issue 12, pp. 2499-509, (2011) (PubMed).

Zhang, Zeng, Zhang, Jiao, Li, Jing, Ouyang, Yuan, Chai, Che, Zhang, Yang: "Suppressor of cytokine signaling 3 promotes bone marrow cells to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression." in: Cancer research, Vol. 69, Issue 4, pp. 1578-86, (2009) (PubMed).

Indraccolo, Minuzzo, Masiero, Pusceddu, Persano, Moserle, Reboldi, Favaro, Mecarozzi, Di Mario, Screpanti, Ponzoni, Doglioni, Amadori: "Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy." in: Cancer research, Vol. 69, Issue 4, pp. 1314-23, (2009) (PubMed).

Lauret, Catelain, Titeux, Poirault, Dando, Dorsch, Villeval, Groseil, Vainchenker, Sainteny, Bennaceur-Griscelli: "Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential." in: Leukemia, Vol. 18, Issue 4, pp. 788-97, (2004) (PubMed).

Tohda, Murata-Ohsawa, Sakano, Nara: "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines." in: International journal of oncology, Vol. 22, Issue 5, pp. 1073-9, (2003) (PubMed).

Liu, Shirakawa, Li, Soma, Oka, Dotto, Fairman, Velazquez, Herlyn: "Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 14-25, (2002) (PubMed).
抗原

DLL4 (delta-Like 4 (DLL4))

别名

DLL4

背景

Background: DELTA-4 (also called delta 4 precursor, delta ligand 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4 and notch ligand DLL4 precursor) is a homolog of the Drosophila delta protein. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. DELTA-4 plays a role in the Notch signaling pathway and activates Notch-1 and Notch-4. DELTA-4 is a membrane protein that is expressed in the vascular endothelium.

基因ID

54567, 9506545

UniProt

Q9NR61

途径

Notch Signaling