DLL4 抗体 (Internal Region)
(6 references)
Quick Overview for DLL4 抗体 (Internal Region) (ABIN129625)
抗原
See all DLL4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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Supplier Product No.
- 600-401-696
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Supplier
- Rockland
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原理
- DELTA-4 Antibody
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交叉反应 （详细）
- DELTA-4 affinity purified antibody is directed against human DELTA-4.
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产品特性
- Synonyms: rabbit anti-DELTA4 antibody, DELTA-4, delta 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4, notch ligand DLL4 precursor, DELTA 4
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
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过滤
- Sterile filtered
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免疫原
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Immunogen: Anti-DELTA-4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Human DELTA-4.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-delta-Like 4 (DLL4) antibody
DLL4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A11G2 unconjugated
anti-delta-Like 4 (DLL4) (AA 313-439) antibodyDLL4 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 4A11F8 unconjugated
anti-delta-Like 4 (DLL4) (AA 215-331) antibodyDLL4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4A11F8 unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibodyDLL4 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal 4A11F8-4A11G2 unconjugated
anti-delta-Like 4 (DLL4) (AA 44-345) antibodyDLL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) (AA 123-221) antibodyDLL4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-delta-Like 4 (DLL4) antibody (PE)DLL4 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal HMD4-2 PE
anti-delta-Like 4 (DLL4) (AA 123-221) antibodyDLL4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E2 unconjugated
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应用备注
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Immunohistochemistry Dilution: 10 μg/mL to 20 μg/mL
Application Note: Anti-DELTA-4 has been tested for use in ELISA, immunohistochemistry and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 74 kDa in size corresponding to DELTA-4 by western blotting in the appropriate cell lysate or extract. For best results use Goat Serum as blocking agent in western blotting.
Western Blot Dilution: 1:500 - 1:2,500
ELISA Dilution: 1:10,000 - 1:50,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.88 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon." in: Development (Cambridge, England), Vol. 138, Issue 12, pp. 2499-509, (2011) (PubMed).
: "Suppressor of cytokine signaling 3 promotes bone marrow cells to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression." in: Cancer research, Vol. 69, Issue 4, pp. 1578-86, (2009) (PubMed).
: "Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy." in: Cancer research, Vol. 69, Issue 4, pp. 1314-23, (2009) (PubMed).
: "Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential." in: Leukemia, Vol. 18, Issue 4, pp. 788-97, (2004) (PubMed).
: "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines." in: International journal of oncology, Vol. 22, Issue 5, pp. 1073-9, (2003) (PubMed).
: "Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 14-25, (2002) (PubMed).
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: "Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon." in: Development (Cambridge, England), Vol. 138, Issue 12, pp. 2499-509, (2011) (PubMed).
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- DLL4 (delta-Like 4 (DLL4))
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别名
- DLL4
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背景
- Background: DELTA-4 (also called delta 4 precursor, delta ligand 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4 and notch ligand DLL4 precursor) is a homolog of the Drosophila delta protein. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. DELTA-4 plays a role in the Notch signaling pathway and activates Notch-1 and Notch-4. DELTA-4 is a membrane protein that is expressed in the vascular endothelium.
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基因ID
- 54567, 9506545
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UniProt
- Q9NR61
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途径
- Notch Signaling
抗原
-
