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PARK7/DJ1 抗体 (C-Term)

Rockland 600-401-691 PARK7 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
Rockland
产品编号 ABIN129620
Supplier Product No.: 600-401-691
发货至: 中国
  • 抗原 See all PARK7/DJ1 (PARK7) 抗体
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    抗原表位
    • 24
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    C-Term
    适用
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    宿主
    • 98
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    克隆类型
    • 94
    • 24
    多克隆
    标记
    • 68
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    This PARK7/DJ1 antibody is un-conjugated
    应用范围
    • 93
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Supplier Product No.
    600-401-691
    Supplier
    Rockland
    原理
    PARK-7 Antibody
    交叉反应 (详细)
    Reactivity occurs against human PARK7 protein.
    产品特性
    Synonyms: rabbit anti-PARK7 antibody, PARK-7, PARK 7, Protein DJ-1, Parkinson disease protein 7, Parkinsonism-associated deglycase, DJ-1 mutant, oncogene DJ1, DJ-1 oncogene product
    纯化方法
    This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase.
    过滤
    Sterile filtered
    免疫原

    Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of Human PARK7 protein.

    Immunogen Type: Conjugated Peptide

    亚型
    IgG
    Top Product
    Discover our top product PARK7 Primary Antibody
  • 应用备注

    Immunohistochemistry Dilution: 2 mg/mL - 5 μg/mL

    Application Note: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 28 kDa in size corresponding to PARK7 by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:500 - 1:2,000

    ELISA Dilution: 1:10,000 - 1:50,000

    Other: User Optimized

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.3 mg/mL
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    有效期
    12 months
  • 抗原
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    别名
    PARK7 (PARK7 产品)
    背景
    Background: The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription.  PARK7 may also function as a redox-sensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA.   PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization. While PARK7 has no proteolytic activity, it does have a weak transforming activity.  PARK7 forms a homodimer and binds to DJBP and PIAS2.  PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization.  Diseases include Early onset autosomal recessive Parkinson Disease 7 and Parkinson Disease Juvenile Type 2.
    基因ID
    11315, 31543380
    UniProt
    Q99497
    途径
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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