MDC1 抗体 (AA 679-694)
Quick Overview for MDC1 抗体 (AA 679-694) (ABIN129583)
抗原
See all MDC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 679-694
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Supplier Product No.
- 600-401-453
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Supplier
- Rockland
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原理
- MDC1 Antibody
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产品特性
- Synonyms: rabbit anti-MDC1 antibody, MDC-1, MDC 1 antibody, Mediation of DNA damage checkpoint 1 antibody, NFBD1, Nuclear factor with BRCT domains 1
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纯化方法
- This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to aa 679-694 of Human MDC1 (mediator of DNA damage checkpoint protein 1). MDC1 is hyper-phosphorylated in an ATM-dependent manner.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Mdc1 (MDC1) (AA 1-100) antibody
MDC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mdc1 (MDC1) antibodyMDC1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mdc1 (MDC1) (AA 31-130) antibodyMDC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mdc1 (MDC1) (AA 1-350) antibodyMDC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mdc1 (MDC1) (N-Term) antibodyMDC1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal P2B11 unconjugated
anti-Mdc1 (MDC1) (N-Term) antibody (HRP)MDC1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal P2B11 HRP
anti-Mdc1 (MDC1) (N-Term) antibody (FITC)MDC1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal P2B11 FITC
anti-Mdc1 (MDC1) (N-Term) antibody (Biotin)MDC1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal P2B11 Biotin
anti-Mdc1 (MDC1) (N-Term) antibody (PE)MDC1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal P2B11 PE
anti-Mdc1 (MDC1) (N-Term) antibody (APC)MDC1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal P2B11 APC
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应用备注
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Application Note: This affinity purified antibody has been tested for use in ELISA against the immunizing peptide. Reactivity in other immunoassays is unknown.
Western Blot Dilution: 1:500- 1:2,000
ELISA Dilution: 1:10,000 - 1:50,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- MDC1 (Mdc1 (MDC1))
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别名
- MDC1
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背景
- Background: Mediator of DNA damage checkpoint protein 1 (MDC1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also it is required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
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基因ID
- 9656
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NCBI登录号
- NP_055456
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UniProt
- Q14676
抗原
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