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HDAC6 抗体 (N-Term)

The 兔 多克隆 anti-HDAC6 antibody (ABIN127242) specifically detects HDAC6 in WB 和 IHC (p). The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN127242
发货至: 中国
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Quick Overview for HDAC6 抗体 (N-Term) (ABIN127242)

抗原

See all HDAC6 抗体
HDAC6 (Histone Deacetylase 6 (HDAC6))

适用

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人, 小鼠, 大鼠

宿主

  • 123
  • 22
  • 1

克隆类型

  • 106
  • 40
多克隆

标记

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This HDAC6 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 27
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    N-Term

    特异性

    The antibody detects ~134 kDa HDAC-6. This antibody does not cross-react with other HDAC proteins including HDAC1, 2, 3, 4, 5, 7, and 8.

    纯化方法

    Affinity Chromatography.

    免疫原

    Synthetic peptide mapping to the N-terminus of mouse HDAC-6.
  • 应用备注

    Western Blot: 0.5-4 μg/mL. Immunohistochemistry: 20 μg/mL. Positive Control: Mouse small intestine tissue lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    0.2 mg/mL

    缓冲液

    PBS, pH 7.2, containing 30 % Glycerol, 0.5 % BSA and 0.01 % thimerosal.

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C/-80 °C

    储存方法

    Store the antibody undiluted at -20 °C or (in aliquots) at -70 °C for longer.
  • 抗原

    HDAC6 (Histone Deacetylase 6 (HDAC6))

    别名

    HDAC6

    背景

    Human HDAC6 (1215 a.a. residues) possesses two separate putative catalytic domains, both of which are fully functional and contribute independently to the overall activity of HDAC6. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. HDAC6 may participate in coordinating expression of a group of genes involved in the remoldeling of chromatin during cell differentiation.Synonyms: HD6, Histone deacetylase 6, JM21, KIAA0901

    基因ID

    10013

    NCBI登录号

    NP_006035

    UniProt

    Q9UBN7

    途径

    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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