Western Blot: 0.5-4 μg/mL, Jurkat cell lysate and mouse small intestine tissue lysate can beused as positive controls. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Apoptosis plays an important role in many cellular processes. Dio-1 (Death Inducer-O bliterator-1), a putative transcription factor, has been indicated to function in the onset of apoptosis. Dio-1 expression is upregulated when an apoptosis is detected. It translocates to the nucleus, and activates apoptosis during limb development. Dio-1 expression can be suppressed by caspase inhibitors and Bcl-2 expression.Synonyms: C20orf158, DATF1, Death-inducer obliterator 1, KIAA0333