TLR4 抗体
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- 抗原 See all TLR4 抗体
- TLR4 (Toll-Like Receptor 4 (TLR4))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TLR4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS)
- 特异性
- This antibody detects TLR4.
- 纯化方法
- Affinity Chromatography on Protein A.
- 免疫原
- Recombinant Human TLR4
- Top Product
- Discover our top product TLR4 Primary Antibody
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- 应用备注
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Western Blot: 0.5-4 μg/mL. Flow Cytometric analysis of cell surface expression of TLR4.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0.2 mg/mL
- 缓冲液
- PBS, pH 7.2 containing 50 % Glycerol, 1 % BSA as stabilizers and 0.02 % Thimerosal as preservative.
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C/-80 °C
- 储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- 抗原
- TLR4 (Toll-Like Receptor 4 (TLR4))
- 别名
- CD284 / TLR4 (TLR4 产品)
- 背景
- TLR4 (Toll-like receptor 4) is a mammalain homologue of the Drosophila toll protein. The human TLR4 is a type-1 transmembrane protein containing 799 amino acid residues. The extracellular domain has leucine-rich repeats and the intracellular domain is similar to that of IL-1 receptor. TLR4 is a receptor for lipopolysaccharide (LPS). In mice that are genetically tolerant to endotoxin, mutations have been identified in the intracellular domain of TLR4 that abolish LPS responsiveness. TLR4 uses a mechanism similar to that of the IL-1 receptor for signal transduction that leads to activation of NF-kB.Synonyms: Toll-like receptor 4
- NCBI登录号
- NM_138554
- UniProt
- O00206
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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