BOK 抗体
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北京 101111
Quick Overview for BOK 抗体 (ABIN126989)
抗原
See all BOK 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody reacts to Bok.
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纯化方法
- Affinity purified
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免疫原
- Synthetic peptide surrounding amino acid 44 of rat BOK.
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应用备注
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Western Blot: 0.5-4g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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缓冲液
- PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- BOK (BCL2-Related Ovarian Killer (BOK))
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别名
- BOK / BCL2L9
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背景
- Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.Synonyms: Bcl-2-like protein 9, Bcl-2-related ovarian killer protein, Bcl2-L-9, Hbok
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基因ID
- 29884
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NCBI登录号
- NP_059008
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UniProt
- Q792S6
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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