MAPT 抗体 (Isoform 13, N-Term)
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Quick Overview for MAPT 抗体 (Isoform 13, N-Term) (ABIN126938)
抗原
See all MAPT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Isoform 13, N-Term
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产品特性
- Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein,Paired helical filament-tau
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纯化方法
- Affinity Purified
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免疫原
- Synthetic peptide corresponding to the N-terminus of of the longest isoform of Human Tau.
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亚型
- IgG1
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应用备注
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Western Blot: 1/1000. Immunoprecipitation: 1/500. Immunohistochemistry: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 50 % Glycerol, 1 % BSA and 0.02 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C/-80 °C
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储存方法
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Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- MAPT (Microtubule-Associated Protein tau (MAPT))
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别名
- MAPT / tau
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背景
- Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
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UniProt
- P10636
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途径
- MAPK Pathway, Microtubule Dynamics, M Phase, Regulation of Cell Size
抗原
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