CCR8 抗体
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北京 101111
Quick Overview for CCR8 抗体 (ABIN122580)
抗原
See all CCR8 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Reacts with C-C Chemokine Receptor 8 (CCR8) (family: GPCR, subfamily: Chemokine)
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纯化方法
- Peptide immunogen affinity column
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免疫原
- Synthetic peptide - KLH conjugated
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应用备注
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Immunohistochemistry with formalin fixed paraffin embedded tissues: 28 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.7, containing 0.01 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-80 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))
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别名
- CDw198 / CCR8
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背景
- CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces endothelial chemotaxis and may function as an HIV-1 co-receptor on primary human cells, contributing to HIV-1-induced thymic pathogenesis. CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. Increased expression has been seen in allergen-challenged atopic asthma. No CCR8 expression was found in mesangial cells of the kidney cortex. ESTs have been isolated from human normal kidney, eye, and B cell/lung/testis libraries and from human brain, germ cell, and pancreas cancer libraries.Synonyms: C-C CKR-8, C-C chemokine receptor type 8, CC-CKR-8, CC-chemokine receptor CHEMR1, CCR-8, CKRL1, CMKBR8, CMKBRL2, Chemokine receptor-like 1, GPR-CY6, TER1
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基因ID
- 1237
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UniProt
- P51685
抗原
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