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LHCGR 抗体 (C-Term)

This anti-LHCGR antibody is a 兔 多克隆 antibody detecting LHCGR in IHC (p). Suitable for 人 和 大鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN122503
发货至: 中国

Quick Overview for LHCGR 抗体 (C-Term) (ABIN122503)

抗原

See all LHCGR 抗体
LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This LHCGR antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    C-Term

    交叉反应 (详细)

    Species reactivity (expected):Rat.
    Species reactivity (tested):Human.

    纯化方法

    Peptide Immunogen Affinity Chromatography.

    免疫原

    Synthetic peptide - KLH conjugated. Epitope: C-terminal domain of human. Remarks: The immunizing peptide shows 78% identity (84% similarity) with Mouse and 94% identity (100% similarity) with Rat.
  • 应用备注

    Immunohistochemistry with Formalin Fixed Paraffin Embedded Tissues (5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS containing 0.09 % Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
    Shelf Life: one year from despatch.

    有效期

    12 months
  • Sand, Bergvall, Ekblad, DAmato, Ohlsson: "Expression and distribution of GnRH, LH, and FSH and their receptors in gastrointestinal tract of man and rat." in: Regulatory peptides, Vol. 187, pp. 24-8, (2013) (PubMed).

  • 抗原

    LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

    别名

    Luteinizing Hormone Receptor (LHCGR)

    背景

    LHCGR is a Glycoprotein Hormone Receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, the luteinizing hormone/choriogonadotropin receptor is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed. LHCGR has been reported in brain, cervix, epididymis, ovary, placenta, prostate, testis, umbilical cord, and uterus. ESTs have been isolated from fetal lung/testis/B-cell and testis libraries.Synonyms: LCGR, LGR2, LH/CG-R, LHCGR, LHR, LHRHR, LSH-R, Luteinizing hormone receptor, Lutropin-choriogonadotropic hormone receptor

    UniProt

    P22888

    途径

    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
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