UBE2N 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for UBE2N 抗体 (C-Term) (ABIN121903)
抗原
See all UBE2N 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
纯化方法
- Ion exchange chromatography
-
免疫原
- A 15 amino acid peptide located near the human UBC13 carboxy-terminus
-
亚型
- IgG
-
-
-
-
应用备注
-
Western Blot: 0.5 μg/mL - 1 μg/mL, this antibody detects a band of approximately 16 kDa in human small intestine cell lystates. Immunohistochemistry on frozen sections: 2 μg/mL, this product requires antigen retrieval using heat treatment prior to staining of paraffin sections, sodium citrate buffer pH 6.0 is recommended for this purpose. Recommended Positive Control: Mouse thymus tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- PBS containing 0.02 % Sodium Azide as preservative
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C/-20 °C
-
储存方法
-
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch. -
有效期
- 12 months
-
-
- UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))
-
背景
- UBC13 is a 16 kDa enzyme which is an important component of the TLR (Toll-like receptor) and IL-1R signalling pathway. UBC13 is DNA-damage inducible protein which forms part of an enzyme complex, with UEV1A, that indirectly activates TAK1 via the ubiquitination of TRAF-6. Ubiquitin modification of proteins is important for error-free DNA repair and for targeting of short-lived or abnormal proteins for degradation.Synonyms: Bendless-like ubiquitin-conjugating enzyme, UBC13, Ubiquitin carrier protein N, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-protein ligase N
-
UniProt
- P61088
-
途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway
抗原
-