CD8 抗体 (FITC)
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- 抗原 See all CD8 抗体
- CD8
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD8 antibody is conjugated to FITC
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The antibody recognizes a conformationally-dependent epitope of CD8 antigen (does not react with formaldehyde-fixed cells, negative in Western Blotting application).
- 交叉反应 (详细)
- Species reactivity (tested):Human.
- 产品特性
- Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain
- 免疫原
- Crude thymus membrane fraction.
- 克隆位点
- MEM-31
- 亚型
- IgG2a
- Top Product
- Discover our top product CD8 Primary Antibody
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- 应用备注
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Flow Cytometry: Human blood cells using 20 μL reagent / 100 μL whole blood or 10^6 cellsin a suspension. Does not work in Immunohistochemistry on formalin fixed cells or Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2 % (w/v) high-grade protease free BSA as a stabilizing agent.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
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Store the antibody at 2-8 °C. DO NOT FREEZE. This product is photosensitive and should be protected from light.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- CD8
- 别名
- CD8 (CD8 产品)
- 背景
- The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
- 基因ID
- 925
- UniProt
- P01732
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