SIT1 抗体
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北京 101111
Quick Overview for SIT1 抗体 (ABIN120658)
抗原
See all SIT1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.
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产品特性
- Synonyms: Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembraneadapter protein, Suppression-inducing transmembrane adapter 1
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纯化方法
- Protein-A affinity chromatography
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纯度
- > 95 % pure (by SDS-PAGE)
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免疫原
- Bacterially produced recombinant intracellular fragment of human SIT.
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亚型
- IgG1
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anti-Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1) antibody
SIT1 适用: 人 WB, IP, ICFC 宿主: 小鼠 Monoclonal SIT-01 unconjugated
anti-Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1) antibody (PE)SIT1 适用: 人 ICFC 宿主: 小鼠 Monoclonal SIT-01 PE
anti-Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1) (AA 161-189), (C-Term) antibodySIT1 适用: 人 WB 宿主: 兔 Polyclonal RB35945 unconjugated
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应用备注
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Flow Cytometry (intracellular staining). Immunoprecipitation. Western Blotting: Western blot analysis demonstrated that SIT is expressed as anapproximately 40 kDa protein that is reduced to approximately 20 kDa by endoglycosidasetreatment.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
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别名
- SIT1 / SIT
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背景
- SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.Synonyms: SHP2-interacting transmembrane adapter protein, Signaling threshold-regulating transmembrane adapter 1, Suppression-inducing transmembrane adapter 1
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基因ID
- 27240
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UniProt
- Q9Y3P8
抗原
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