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P-Selectin 抗体 (PE)

SELP 适用: 人, 大鼠, 绵羊, 山羊 FACS 宿主: 小鼠 Monoclonal Psel-KO-2-12 PE
产品编号 ABIN120299
发货至: 中国
  • 抗原 See all P-Selectin (SELP) 抗体
    P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
    适用
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    人, 大鼠, 绵羊, 山羊
    宿主
    • 69
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    小鼠
    克隆类型
    • 66
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    单克隆
    标记
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    This P-Selectin antibody is conjugated to PE
    应用范围
    • 82
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    Flow Cytometry (FACS)
    特异性
    This antibody recognises the CD62P cell surface antigen, a 140 kDa glycoprotein also known as P-selectin. Clone Psel.KO.2.12 is reported to inhibit P-selectin-dependent adhesion between HL60 cells and P-selectin transfected COS cells. We recommend the use of Azide Free, Low Endotoxin CD62P antibody Cat.-No SM2262LE for this purpose.Cat.-No
    纯化方法
    Affinity Chromatography on Protein G
    免疫原
    CD62P transfected 300.19 cells. Spleen cells from immunised CD62P knock-out mice (Strain C57/B6) were fused with cells of the NS-1 myeloma cell line.
    克隆位点
    Psel-KO-2-12
    亚型
    IgG1
    Top Product
    Discover our top product SELP Primary Antibody
  • 应用备注
    Flow Cytometry (Neat).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore with 1.0 mL distilled water
    浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.09 % Sodium Azide, 1 % BSA and 5 % Sucrose
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in alqiuots) at -20 °C for longer.
  • 抗原
    P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
    别名
    CD62P / P-Selectin (SELP 产品)
    别名
    PSELECT antibody, CD62 antibody, CD62P antibody, GMP140 antibody, GRMP antibody, LECAM3 antibody, PADGEM antibody, PSEL antibody, GMP-140 antibody, Grmp antibody, selectin P antibody, selectin, platelet antibody, Selp antibody, SELP antibody
    背景
    CD62P is a member of the small selectin family of cellular adhesion molecules, which also includes CD62E and CD62L. Its structure, similar to the other members of the selectin family, consists of an N terminal lectin like domain of C type, followed by an epidermal growth factor like motif, a series of short consensus repeats, a transmembrane domain, and a cytoplasmic tail. The CD62P antigen is a 140 kDa glycoprotein, located in the alpha granules and the dense granules of platelets and endothelial cells. Activation of these cells results in rapid mobilization of CD62P from the storage granules to the cell surface. Activated platelets have a stable CD62P expression, while the endothelial cells lose CD62P expression within 1 h of activation, because of endocytosis of the molecule. CD62P is also expressed on megakaryocytes, but resting platelets and endothelial cells show no surface staining of CD62P.Synonyms: CD62 antigen-like family member P, GMP-140, GMRP, GRMP, Granule membrane protein 140, LECAM3, Leukocyte-endothelial cell adhesion molecule 3, PADGEM, SELP
    基因ID
    6403
    NCBI登录号
    NP_002996
    UniProt
    P16109
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