CD80 抗体
Quick Overview for CD80 抗体 (ABIN119430)
抗原
See all CD80 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognises the CD80 cell surface antigen, also known as B7-1.
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纯化方法
- Affinity chromatography on Protein A
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亚型
- IgG1
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应用备注
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Flow Cytometry. Immunoprecipitation. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS
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储存液
- Azide free
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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- CD80
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别名
- CD80
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背景
- CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines. CD80 is expressed by activated B cells, and is important in B cell - T cell interactions, being a ligand of CD28 and CD152 (CTLA-4).Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
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基因ID
- 941
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NCBI登录号
- NP_005182
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UniProt
- P33681
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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