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CD11b 抗体

Name: CD11b 抗体
SKU: ABIN118516
Availability: OutOfStock

ITGAM 适用: 人, 猴 FACS, IP, IHC (fro), Func 宿主: 小鼠 Monoclonal ICRF44 unconjugated

Staining of human peripheral blood granulocytes with Mouse anti Human CD11b (ABIN118516). (CD11b 抗体)

1 image

(1 reference)

产品编号 ABIN118516

发货至: 中国

Datasheet as PDF

抗原 See all CD11b (ITGAM) 抗体

CD11b (ITGAM) (Integrin alpha M (ITGAM))
适用
259

168

62

33

17

17

16

14

11

7

7

5

5

2

2

1
人, 猴
宿主
137

105

103

4

1

1
小鼠
Compatible Secondaries
克隆类型
251

96

1
单克隆
标记
120

37

29

26

20

10

7

6

6

6

5

5

4

4

4

4

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD11b antibody is un-conjugated
应用范围
260

84

76

72

59

40

36

27

22

20

13

13

7

6

5

5

4

3

2

2

2

2

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

特异性

This antibody recognizes the CD11b cell surface glycoprotein. Clone ICRF44 has been reported to have various functional effects on monocytes, blocking adhesion and stimulating cytokine and chemokine release.

无交叉反应

猫

交叉反应（详细）

Species reactivity (tested):Human, Cynomolgus Monkey , Rhesus Monkey, Baboon.

纯化方法

Affinity Chromatography on Protein G

免疫原

Rheumatoid synovial cells and Human monocytes. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the mouse Sp2/0 myeloma cell line.

克隆位点

ICRF44

亚型

IgG1

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应用备注

Flow Cytometry (use 10 μL of 1:10 - 1:100 diluted antibody to label 10^6 cells or 100 μL whole blood). Immunoprecipitation Immunohistochemistry on frozen sections (1:100 - 1:1000) Recommended positive control tissue: Human tonsil. Not suitable for paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

PBS, 0.09 % Sodium Azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the reconstituted antibody at 2-8 °C for one month (add 0.09% Sodium Azide) or at -20 °C for longer.
Sotiriou, Orlova, Al-Fakhri, Ihanus, Economopoulou, Isermann, Bdeir, Nawroth, Preissner, Gahmberg, Koschinsky, Chavakis: "Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 3, pp. 559-61, (2006) (PubMed).
抗原

CD11b (ITGAM) (Integrin alpha M (ITGAM))

别名

CD11b (ITGAM 产品)

别名

CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody

背景

CD11b is a 165 kD molecule also know as the alpha-M integrin, MAC-1 and CR3. This molecule is expressed as a heterodimer in association with the beta-2 integrin and is found on monocytes, granulocytes, NK cells and some peripheral blood lymphocytes. ICR44 significantly blocks homotypic PNM aggregation on response to FMLP (3,4).Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor

基因ID

3684

NCBI登录号

NP_000623

UniProt

P11215

途径

Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation