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CD4 抗体 (Non-Polymorphic Site) (PE)

Name: CD4 抗体 (Non-Polymorphic Site) (PE)
SKU: ABIN118165
Availability: OutOfStock

CD4 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal YTS177-9 PE

产品编号 ABIN118165

发货至: 中国

Datasheet as PDF

抗原 See all CD4 抗体

CD4
抗原表位
29

16

16

16

16

9

7

6

5

4

4

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Non-Polymorphic Site
适用
306

189

111

38

24

20

19

18

14

10

10

10

8

7

6

6

6

6

6

2

2

1

1

1

1
小鼠
宿主
288

137

100

4

3

1
大鼠
Compatible Secondaries
克隆类型
396

132

3
单克隆
标记
179

60

52

41

30

13

12

9

9

9

7

6

4

4

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This CD4 antibody is conjugated to PE
应用范围
428

177

96

76

76

66

58

42

39

34

28

24

10

7

7

7

6

6

5

5

3

3

2

2

2

1

1

1

1

1
Flow Cytometry (FACS)

特异性

This antibody reacts with the CD4 antigen, non polymorphic epitope. The antibody is reported to block MHC class II dependant T-cell responses in vitro and in vivo and induces tolerance. We recommend SM019A for such studies.

纯化方法

Affinity chromatography on Protein G

免疫原

Mouse spleen cells. Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1.2.3 rat myeloma cell line.

克隆位点

YTS177-9

亚型

IgG2a

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应用备注

Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
溶解方式

Restore with 1 mL (SM019R) or 0.25 (SM019RT) distilled water.

浓度

1.0 mg/mL

缓冲液

PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE! Protect from light!
抗原

CD4

别名

CD4 (CD4 产品)

别名

cd4 antibody, L3T4 antibody, Ly-4 antibody, CD4mut antibody, W3/25 antibody, p55 antibody, CD4 molecule antibody, carcinoembryonic antigen-related cell adhesion molecule 5 antibody, T-cell surface glycoprotein CD4 antibody, CD4 antigen antibody, Cd4 molecule antibody, CD4 antibody, LOC100125525 antibody, cd4 antibody, Cd4 antibody

背景

CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1), IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin Intracellular ligands: p56Lck CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus, CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4

基因ID

12504

NCBI登录号

NP_038516

UniProt

P06332

途径

TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events