PPARD 抗体 (N-Term)
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Quick Overview for PPARD 抗体 (N-Term) (ABIN118017)
抗原
See all PPARD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This affinity purified antibody is directed against Mouse PPAR delta protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from Mouse and Rat sources based on 100 % homology for the immunogen sequence. Cross reactivity with PPAR delta protein from Human, Chimpanzee and Rabbit may occur as this sequence shows 85 % homology with the protein from these sources. Cross reactivity with PPAR delta homologues from other sources has not been determined. No reactivity is expected against other subtypes of PPAR.
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纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide corresponding to amino acids near the amino terminus of Mouse PPAR delta.
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anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (AA 1-361) antibody
PPARD 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4E3-1B11 unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (AA 56-165) antibodyPPARD 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (C-Term) antibodyVerified PPARD 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (C-Term) antibodyPPARD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (AA 102-361) antibodyPPARD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) antibodyPPARD 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 小鼠 Monoclonal 2F9 unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (N-Term) antibodyPPARD 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) (AA 2-100) antibodyPPARD 适用: 人 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) antibodyPPARD 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Peroxisome Proliferator-Activated Receptor delta (PPARD) antibodyPPARD 适用: 人, 小鼠, 大鼠 IHC (p), IF 宿主: 小鼠 Monoclonal 5F4 unconjugated
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应用备注
- This antibody has been tested for use in ELISA (1/600,000) and Western blot(1/500-1/5,000). Expect a single band approximately 43 kDa in size corresponding to PPAR delta by Westernblot in the appropriate tissue or cell lysate.
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限制
- 仅限研究用
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浓度
- 2.03 mg/mL (by UV absorbance at 280 nm)
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缓冲液
- 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, containing 0.01 % (w/v) Sodium Azide as preservative.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 2-8 °C.
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- PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))
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别名
- PPAR-delta
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背景
- Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are liganddependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPARalpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.Synonyms: NR1C2, NUCI, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, PPAR-beta, PPARB, PPARD, Peroxisome proliferator-activated receptor delta
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基因ID
- 19015
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NCBI登录号
- NP_035275
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UniProt
- P35396
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途径
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation
抗原
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