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CD226 抗体

Cited in 1 publication. This anti-CD226 antibody is a 小鼠 单克隆 antibody detecting CD226 in FACS 和 Func. Suitable for 人.
产品编号 ABIN1177314
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CD226 抗体 (ABIN1177314)

抗原

See all CD226 抗体
CD226

适用

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宿主

  • 66
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小鼠

克隆类型

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  • 1
单克隆

标记

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This CD226 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Functional Studies (Func)

克隆位点

DX11
  • 纯化方法

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    过滤

    0.2 μm filtered

    内毒素水平

    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

    亚型

    IgG1 kappa
  • 限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

    储存液

    Azide free

    储存条件

    4 °C

    储存方法

    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Shibuya, Campbell, Hannum, Yssel, Franz-Bacon, McClanahan, Kitamura, Nicholl, Sutherland, Lanier, Phillips: "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes." in: Immunity, Vol. 4, Issue 6, pp. 573-81, (1996) (PubMed).

  • 抗原

    CD226

    别名

    CD226

    背景

    Reacts with DNAX accessory molecule-1 (DNAM-1), a 65 kDa transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. DNAM-1 is expressed on the majority of T cells, NK cells, monocytes, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. DNAM-1 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. DNAM-1 is a tyrosinephosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. DX11 inhibits T- and NKcell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells.
    Synonyms: DNAM-1

    途径

    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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