WIPF1 抗体 (pSer488) (PE)
Quick Overview for WIPF1 抗体 (pSer488) (PE) (ABIN1177221)
抗原
See all WIPF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer488
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品牌
- BD Phosflow™
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纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Phosphorylated Human WIP Peptide
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亚型
- IgG1 kappa
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样本量
- 20 μL
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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: "The verprolin family of proteins: regulators of cell morphogenesis and endocytosis." in: FEBS letters, Vol. 579, Issue 24, pp. 5253-9, (2005) (PubMed).
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: "The verprolin family of proteins: regulators of cell morphogenesis and endocytosis." in: FEBS letters, Vol. 579, Issue 24, pp. 5253-9, (2005) (PubMed).
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- WIPF1 (WAS/WASL Interacting Protein Family, Member 1 (WIPF1))
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别名
- WIP
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背景
- Wiskott-Adrich syndrome protein (WASP)-Interacting Protein (WIP) is a member of the verprolin family of proteins that regulate cytoskeletal organization in a wide variety of cellular activities, including endocytosis, cellular adhesion and migration, mast cell degranulation, and lymphocyte activation. The 503-amino acid WIP protein contains binding sites for actin (globular and filamentous) and other proteins that are involved in the regulation of actin polymerization, such as WASP, N-WASP, profilin, cortactin, Hck, and NCK. As its functions imply, WIP is localized in actin-rich cell structures. The K32-824 monoclonal antibody recognizes the phosphorylated serine 488 (pS488) of human WIP. The orthologous phosphorylation sites in mouse and rat WIP are S478 and S472, respectively.
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途径
- RTK signaling
抗原
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