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P-Selectin 抗体

SELP 适用: 小鼠 FACS, IP, ELISA, IHC (fro), IF, BR 宿主: 大鼠 Monoclonal RB40-34 unconjugated
产品编号 ABIN1177016
发货至: 中国
  • 抗原 See all P-Selectin (SELP) 抗体
    P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
    适用
    • 101
    • 35
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    小鼠
    宿主
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    大鼠
    克隆类型
    • 62
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    单克隆
    标记
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    This P-Selectin antibody is un-conjugated
    应用范围
    • 81
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    • 24
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    Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Blocking Reagent (BR)
    品牌
    BD Pharmingen™
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    过滤
    0.2 μm filtered
    内毒素水平
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    免疫原
    P-selectin-IgG1 Fusion
    克隆位点
    RB40-34
    亚型
    IgG1 lambda
    Top Product
    Discover our top product SELP Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    储存液
    Azide free
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Hirata, Furie, Furie: "P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 8, pp. 4307-13, (2002) (PubMed).

    Katakai, Mori, Masuda, Shimizu: "Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or alpha(4)beta(7)-integrin at the lesions of autoimmune gastritis." in: International immunology, Vol. 14, Issue 2, pp. 167-75, (2002) (PubMed).

    Tietz, Allemand, Borges, von Laer, Hallmann, Vestweber, Hamann: "CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 2, pp. 963-70, (1998) (PubMed).

    Austrup, Vestweber, Borges, Löhning, Bräuer, Herz, Renz, Hallmann, Scheffold, Radbruch, Hamann: "P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues." in: Nature, Vol. 385, Issue 6611, pp. 81-3, (1997) (PubMed).

    Yang, Galipeau, Kozak, Furie, Furie: "Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor." in: Blood, Vol. 87, Issue 10, pp. 4176-86, (1996) (PubMed).

    Bosse, Vestweber: "Only simultaneous blocking of the L- and P-selectin completely inhibits neutrophil migration into mouse peritoneum." in: European journal of immunology, Vol. 24, Issue 12, pp. 3019-24, (1995) (PubMed).

    Ley, Bullard, Arbonés, Bosse, Vestweber, Tedder, Beaudet: "Sequential contribution of L- and P-selectin to leukocyte rolling in vivo." in: The Journal of experimental medicine, Vol. 181, Issue 2, pp. 669-75, (1995) (PubMed).

  • 抗原
    P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
    别名
    CD62P (P-selectin) (SELP 产品)
    别名
    PSELECT antibody, CD62 antibody, CD62P antibody, GMP140 antibody, GRMP antibody, LECAM3 antibody, PADGEM antibody, PSEL antibody, GMP-140 antibody, Grmp antibody, selectin P antibody, selectin, platelet antibody, Selp antibody, SELP antibody
    背景
    The RB40.34 antibody reacts with mouse P-selectin (CD62P), a 140 kDa protein which is expressed on activated platelets, activated endothelial cells, and megakaryocytes. P-selectin mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells, mediates leukocyte rolling, and is involved in the migration of leukocytes into inflamed tissues. CD24 and CD162 (PSGL-1) are ligands of CD62P. mAb RB40.34 can block mouse P-selectin binding to its ligands in vitro and in vivo.
    Synonyms: P-selectin
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