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ICOS 抗体

Name: ICOS 抗体
SKU: ABIN1176983
Availability: OutOfStock

There are 9+ publications for this product available. The 大鼠单克隆 anti-ICOS antibody is suitable to detect ICOS in samples from 小鼠. It has been validated for FACS 和 BR.

(9 references)

产品编号 ABIN1176983

发货至: 中国

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Quick Overview for ICOS 抗体 (ABIN1176983)

抗原

See all ICOS 抗体

ICOS (Inducible T-Cell Co-Stimulator (ICOS))

适用

小鼠

宿主

大鼠

克隆类型

单克隆

标记

This ICOS antibody is un-conjugated

应用范围

Flow Cytometry (FACS), Blocking Reagent (BR)

克隆位点

7E-17G9

Discover our top product ICOS Primary Antibody

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

过滤

0.2 μm filtered

内毒素水平

Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

免疫原

Mouse Icos cDNA and ICOS hexahistidine fusion protein

亚型

IgG2b kappa
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibody
ICOS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 156-185) antibody
ICOS 适用: 人 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) (Internal Region) antibody
Verified ICOS 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) antibody
ICOS 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-200) antibody
ICOS 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) antibody
ICOS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 1-199) antibody
ICOS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibody
ICOS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G4 unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) antibody
ICOS 适用: 人 IHC, FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal ISA-3 unconjugated

anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 39-133) antibody
ICOS 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

应用备注

Since this antigen is expressed at only moderate density on activated T lymphocytes, it may be desirable to amplify the staining by using a biotinylated second-step antibody with a bright third-step reagent, such as Streptavidin-PE (Cat. No. 554061). Furthermore, we have found that polyclonal goat anti-rat Ig is weakly reactive with this rat IgG2b mAb, so we recommend the use of biotinylated anti-rat IgG2b mAb RG7/11.1 (Cat. No. 553898) as the second step.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

储存液

Azide free

储存条件

4 °C

储存方法

Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Buonfiglio, Bragardo, Redoglia, Vaschetto, Bottarel, Bonissoni, Bensi, Mezzatesta, Janeway Jr, Dianzani: "The T cell activation molecule H4 and the CD28-like molecule ICOS are identical." in: European journal of immunology, Vol. 30, Issue 12, pp. 3463-7, (2001) (PubMed).

Chambers: "The expanding world of co-stimulation: the two-signal model revisited." in: Trends in immunology, Vol. 22, Issue 4, pp. 217-23, (2001) (PubMed).

Dong, Temann, Flavell: "Cutting edge: critical role of inducible costimulator in germinal center reactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 6, pp. 3659-62, (2001) (PubMed).

Gonzalo, Delaney, Corcoran, Goodearl, Gutierrez-Ramos, Coyle: "Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 1-5, (2001) (PubMed).

Schwartz: "Immunology. It takes more than two to tango." in: Nature, Vol. 409, Issue 6816, pp. 31-2, (2001) (PubMed).

Sperling, Bluestone: "ICOS costimulation: It's not just for TH2 cells anymore." in: Nature immunology, Vol. 2, Issue 7, pp. 573-4, (2001) (PubMed).

Wallin, Liang, Bakardjiev, Sha: "Enhancement of CD8+ T cell responses by ICOS/B7h costimulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 132-9, (2001) (PubMed).

Mages, Hutloff, Heuck, Büchner, Himmelbauer, Oliveri, Kroczek: "Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand." in: European journal of immunology, Vol. 30, Issue 4, pp. 1040-7, (2000) (PubMed).

McAdam, Chang, Lumelsky, Greenfield, Boussiotis, Duke-Cohan, Chernova, Malenkovich, Jabs, Kuchroo, Ling, Collins, Sharpe, Freeman: "Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 5035-40, (2000) (PubMed).
抗原

ICOS (Inducible T-Cell Co-Stimulator (ICOS))

别名

CD278

背景

The 7E.17G9 antibody reacts with CD278, the Inducible Costimulatory molecule (ICOS), a 47-57 kDa homodimeric glycoprotein of the CD28 family of costimulatory molecules. ICOS is expressed on subpopulations of CD4-CD8- and CD4+CD8- (but not CD4-CD8+ or CD4+CD8+) thymocytes, on some T-cell lines, and on small numbers of peripheral leukocytes. It is upregulated on T lymphocytes following activation via the T-cell receptor. The T-cell activation marker H4 is the same molecule as ICOS. ICOS is a costimulatory receptor, and its ligand on antigen-presenting cells has been called B7RP-1, GL50, B7h, B7-H2, or LICOS. There is considerable evidence that the interaction of ICOS with its ligand is involved in the regulation of many, but not all, T-cell-mediated immune responses.
Synonyms: ICOS

途径

Cancer Immune Checkpoints