(9 references)-
- 抗原 See all ICOS 抗体
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This ICOS antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Blocking Reagent (BR)
- 品牌
- BD Pharmingen™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- 免疫原
- Mouse Icos cDNA and ICOS hexahistidine fusion protein
- 克隆位点
- 7E-17G9
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product ICOS Primary Antibody
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anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibody
ICOS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 156-185) antibodyICOS 适用: 人 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (Internal Region) antibodyVerified ICOS 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-200) antibodyICOS 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 1-199) antibodyICOS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibodyICOS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS 适用: 人 IHC, FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal ISA-3 unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 39-133) antibodyICOS 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Since this antigen is expressed at only moderate density on activated T lymphocytes, it may be desirable to amplify the staining by using a biotinylated second-step antibody with a bright third-step reagent, such as Streptavidin-PE (Cat. No. 554061). Furthermore, we have found that polyclonal goat anti-rat Ig is weakly reactive with this rat IgG2b mAb, so we recommend the use of biotinylated anti-rat IgG2b mAb RG7/11.1 (Cat. No. 553898) as the second step.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "The T cell activation molecule H4 and the CD28-like molecule ICOS are identical." in: European journal of immunology, Vol. 30, Issue 12, pp. 3463-7, (2001) (PubMed).
: "The expanding world of co-stimulation: the two-signal model revisited." in: Trends in immunology, Vol. 22, Issue 4, pp. 217-23, (2001) (PubMed).
: "Cutting edge: critical role of inducible costimulator in germinal center reactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 6, pp. 3659-62, (2001) (PubMed).
: "Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 1-5, (2001) (PubMed).
: "Immunology. It takes more than two to tango." in: Nature, Vol. 409, Issue 6816, pp. 31-2, (2001) (PubMed).
: "ICOS costimulation: It's not just for TH2 cells anymore." in: Nature immunology, Vol. 2, Issue 7, pp. 573-4, (2001) (PubMed).
: "Enhancement of CD8+ T cell responses by ICOS/B7h costimulation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 132-9, (2001) (PubMed).
: "Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand." in: European journal of immunology, Vol. 30, Issue 4, pp. 1040-7, (2000) (PubMed).
: "Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 5035-40, (2000) (PubMed).
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: "The T cell activation molecule H4 and the CD28-like molecule ICOS are identical." in: European journal of immunology, Vol. 30, Issue 12, pp. 3463-7, (2001) (PubMed).
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- 抗原
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- 别名
- CD278 (ICOS 产品)
- 背景
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The 7E.17G9 antibody reacts with CD278, the Inducible Costimulatory molecule (ICOS), a 47-57 kDa homodimeric glycoprotein of the CD28 family of costimulatory molecules. ICOS is expressed on subpopulations of CD4-CD8- and CD4+CD8- (but not CD4-CD8+ or CD4+CD8+) thymocytes, on some T-cell lines, and on small numbers of peripheral leukocytes. It is upregulated on T lymphocytes following activation via the T-cell receptor. The T-cell activation marker H4 is the same molecule as ICOS. ICOS is a costimulatory receptor, and its ligand on antigen-presenting cells has been called B7RP-1, GL50, B7h, B7-H2, or LICOS. There is considerable evidence that the interaction of ICOS with its ligand is involved in the regulation of many, but not all, T-cell-mediated immune responses.
Synonyms: ICOS - 途径
- Cancer Immune Checkpoints
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