(1 reference)-
- 抗原 See all TBK1 抗体
- TBK1 (TANK-Binding Kinase 1 (TBK1))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TBK1 antibody is conjugated to PE
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Phosflow™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human TBK1 C terminus Recombinant Protein
- 克隆位点
- 637Ig11-2
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product TBK1 Primary Antibody
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anti-TANK-Binding Kinase 1 (TBK1) (AA 440-729) antibody
TBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) antibodyTBK1 适用: 人 WB, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibodyTBK1 适用: 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 9-310) antibodyTBK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 150-181) antibodyTBK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB16573 unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 364-585) antibodyTBK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (C-Term) antibodyTBK1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 563-577) antibodyTBK1 适用: 人 WB 宿主: 小鼠 Monoclonal 108A429 unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 644-661) antibodyTBK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 74-123) antibodyTBK1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, Pig, 猴, 马, 豚鼠, 斑马鱼, Hamster, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 样本量
- 20 μL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." in: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).
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: "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." in: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).
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- 抗原
- TBK1 (TANK-Binding Kinase 1 (TBK1))
- 别名
- TBK1 (TBK1 产品)
- 别名
- nak antibody, t2k antibody, TBK1 antibody, wu:fk70c05 antibody, zgc:136548 antibody, NAK antibody, T2K antibody, 1200008B05Rik antibody, AI462036 antibody, AW048562 antibody, TANK binding kinase 1 L homeolog antibody, TANK binding kinase 1 antibody, TANK-binding kinase 1 antibody, tbk1.L antibody, TBK1 antibody, tbk1 antibody, Tbk1 antibody
- 背景
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NF-kB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. In most cells, NF-kB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkBalpha, IkBbeta, and IkBepsilon. Stimulation induces the release, activation, and nuclear translocation of NF-kB. Release of NF-kB results from the phosphorylation and proteolytic degradation of the IkB proteins. Two cytokine-inducible IkappaB kinases (IKKa and IKKb) phosphorylate and target the IkB proteins for degradation via the ubiquitin pathway. IKKg/NEMO, a third member of the IKK complex, functions as a regulatory subunit and interacts directly with IKKb. TBK1 (TANK-binding kinase 1, also known as T2K or NAK), a protein of 729 amino acids, is another member of the IKK family of kinases regulating NF-kB downstream of the tumor necrosis factor and Toll-like receptor pathways. TBK1 forms a complex with the adaptor proteins TANK (TRAF-associated NF-kB activator) and TRAF2 (TNF-receptor-associated factor 2), and this oligomer is required for activation and phosphorylation of TBK1 at serine 172. The 637Ig11.2 monoclonal antibody recognizes human TBK1, regardless of phosphorylation status. Our in-house testing is performed on a cell line that has been co-transfected with TBK1 and IRF-7 because we have been unable to detect endogenous TBK1 by western blotting of lysates from activated cell lines (HeLa activated with PMA and A431 activated with PDGF). In the transfectants, the over-expression of TBK1 is necessary for phosphorylation of IRF-7, but the presence of IRF-7 does not affect TBK1 expression or phosphorylation. We confirmed that mAb 637Ig11.2 does not cross-react with IRF-7 by western blot analysis using the purified antibody.
Synonyms: T2K, NAK - 途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome
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